The effects of melatonin on tinnitus and sleep.
To determine if melatonin improves tinnitus and if this improvement is related to improvement in sleep.
The effects of melatonin on tinnitus and sleep. Read More »
melatonin
Phase-dependent treatment of delayed sleep phase syndrome with melatonin.
Delayed sleep phase syndrome (DSPS) is a circadian-rhythm sleep disorder characterized by abnormally late sleep and wake times. Melatonin, taken in the evening, advances sleep and circadian phase in patients with DSPS. However, little is known about the most effective dose or time of administration. In the present study, we tested the effectiveness of melatonin to advance the timing of sleep and circadian phase in individuals with DSPS.
Phase-dependent treatment of delayed sleep phase syndrome with melatonin. Read More »
Melatonin levels decrease in type 2 diabetic patients with cardiac autonomic neuropathy.
The present study has been designed to determine melatonin levels in type 2 diabetic patients and test the relationship between the autonomic nervous system and melatonin dynamics.
Melatonin levels decrease in type 2 diabetic patients with cardiac autonomic neuropathy. Read More »
Add-on melatonin improves sleep behavior in children with epilepsy: randomized, double-blind, placebo-controlled trial.
This double-blind, randomized, placebo-controlled study in epileptic children, aged 3 to 12 years, evaluated the effect of add-on melatonin on the sleep behavior of these children on sodium valproate monotherapy using a parental questionnaire.
Melatonin and the circadian system: contributions to successful female reproduction.
To summarize the role of melatonin and circadian rhythms in determining optimal female reproductive physiology, especially at the peripheral level.
Melatonin and the circadian system: contributions to successful female reproduction. Read More »
Melatonin increases anagen hair rate in women with androgenetic alopecia or diffuse alopecia: results of a pilot randomized controlled trial.
In addition to the well-known hormonal influences of testosterone and dihydrotestosterone on the hair cycle, melatonin has been reported to have a beneficial effect on hair growth in animals. The effect of melatonin on hair growth in humans has not been investigated so far.
Melatonin in patients with reduced REM sleep duration: two randomized controlled trials.
Recent data suggest that melatonin may influence human physiology, including the sleep-wake cycle, in a time-dependent manner via the body’s internal clock.
Melatonin in patients with reduced REM sleep duration: two randomized controlled trials. Read More »
Antioxidant properties of the melatonin metabolite N1-acetyl-5-methoxykynuramine (AMK): scavenging of free radicals and prevention of protein destruction.
In numerous experimental systems, the neurohormone melatonin has been shown to protect against oxidative stress, an effect which appears to be the result of a combination of different actions. In this study, we have investigated the possible contribution to radical scavenging by substituted kynuramines formed from melatonin via pyrrole ring cleavage.
Double blind study of melatonin effects on the sleep-wake rhythm, cognitive and non-cognitive functions in Alzheimer type dementia.
Previously, we reported that morning bright light therapy improved sleep time and cognitive function in Alzheimer type of dementia.
Melatonin ameliorates neurologic damage and neurophysiologic deficits in experimental models of stroke.
This review summarizes the numerous reports that have documented the neuroprotective actions of melatonin in experimental models of ischemia/reperfusion injury (stroke).
Administration of melatonin after onset of ischemia reduces the volume of cerebral infarction in a rat middle cerebral artery occlusion stroke model.
In both permanent and transient 3-hour middle cerebral artery occlusion rat stroke models, a single intraperitoneal injection of melatonin at 5 or 15 mg/kg given before ischemia was shown to reduce infarct volume at 72 hours. The present study was conducted to examine the treatment time window when melatonin was commenced after onset of ischemia.
Melatonin-immune system relationships.
In this paper we review the historical milestones that first highlighted the existence of a relationship between melatonin and the immune system and we summarize data from experiments which correlate the rhythmic production of melatonin with the rhythmic activity of the immune system.
Melatonin-immune system relationships. Read More »
Effects of melatonin treatment in septic newborns.
Free radicals have been implicated in the pathogenesis of neonatal sepsis and its complications.
Effects of melatonin treatment in septic newborns. Read More »
Randomized, double-blind clinical trial, controlled with placebo, of the toxicology of chronic melatonin treatment.
The objective of the present study was to assess the toxicology of melatonin (10 mg), administered for 28 days to 40 volunteers randomly assigned to groups receiving either melatonin (N = 30) or placebo (N = 10) in a double-blind fashion.
Long-term melatonin administration does not alter pituitary-gonadal hormone secretion in normal men.
The role of melatonin in the regulation of reproduction in humans is still controversial. In the present study the effects of melatonin were examined, 6 mg given orally every day at 1700 h for 1 month in a double-blind, placebo controlled fashion, on the nocturnal secretory profiles of luteinizing hormone (LH), follicle stimulating hormone (FSH), testosterone and inhibin beta in six healthy adult men.
Melatonin in epilepsy: first results of replacement therapy and first clinical results.
At a single evening dose of 5-10 mg, melatonin (MLT), the pineal gland hormone, can exert a positive effect on the frequency of epileptic attacks in children with sleep disturbances of various etiologies.
Melatonin in epilepsy: first results of replacement therapy and first clinical results. Read More »