free radicals

Melatonin Supplementation in Iranian Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Exploring Oxidative Stress and Inflammation

Latest facts, Other diseases /

Background: Diabetes mellitus is a global health challenge characterized by oxidative stress (OS) and persistent inflammation, which contribute to the progression of complications. Melatonin, a multifaceted hormone known for its potent antioxidant and anti-inflammatory properties, has emerged as a potential therapeutic intervention in diabetes. This systematic review and meta-analysis aimed to evaluate the effects of melatonin

Melatonin Supplementation in Iranian Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Exploring Oxidative Stress and Inflammation Read More »

Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis.

Cancer, Immune system /

There is highly credible evidence that melatonin mitigates cancer at the initiation, progression and metastasis phases. In many cases, the molecular mechanisms underpinning these inhibitory actions have been proposed. What is rather perplexing, however, is the large number of processes by which melatonin reportedly restrains cancer development and growth.

Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis. Read More »

Melatonin as an antioxidant: under promises but over delivers.

Basic facts, Cancer, Cardiovascular system, Other diseases, Viral diseases /

Melatonin is uncommonly effective in reducing oxidative stress under a remarkably large number of circumstances. It achieves this action via a variety of means: direct detoxification of reactive oxygen and reactive nitrogen species and indirectly by stimulating antioxidant enzymes while suppressing the activity of pro-oxidant enzymes.

Melatonin as an antioxidant: under promises but over delivers. Read More »

Melatonin: action as antioxidant and potential applications in human disease and aging.

Basic facts, Cancer, Cardiovascular system, Metabolism, Viral diseases /

This review aims at describing the beneficial properties of melatonin related to its antioxidant effects. Oxidative stress, i.e., an imbalance between the production of reactive oxygen species and antioxidant defences, is involved in several pathological conditions such as cardiovascular or neurological disease, and in aging. Therefore, research for antioxidants has developed. However, classical antioxidants often failed to exhibit beneficial effects, especially in metabolic diseases.

Melatonin: action as antioxidant and potential applications in human disease and aging. Read More »

Beneficial effects of melatonin in cardiovascular disease.

Cardiovascular system /

The experimental data obtained from both human and rodent studies suggest that melatonin may have utility in the treatment of several cardiovascular conditions. In particular, melatonin’s use in reducing the severity of essential hypertension should be more widely considered. In rodent studies melatonin has been shown to be highly effective in limiting abnormal cardiac physiology and the loss of critical heart tissue resulting from ischemia/reperfusion injury.

Beneficial effects of melatonin in cardiovascular disease. Read More »

One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species?

Immune system, Viral diseases /

Melatonin is a highly conserved molecule. Its presence can be traced back to ancient photosynthetic prokaryotes. A primitive and primary function of melatonin is that it acts as a receptor-independent free radical scavenger and a broad-spectrum antioxidant.

One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species? Read More »

Antioxidant properties of the melatonin metabolite N1-acetyl-5-methoxykynuramine (AMK): scavenging of free radicals and prevention of protein destruction.

Immune system, Viral diseases /

In numerous experimental systems, the neurohormone melatonin has been shown to protect against oxidative stress, an effect which appears to be the result of a combination of different actions. In this study, we have investigated the possible contribution to radical scavenging by substituted kynuramines formed from melatonin via pyrrole ring cleavage.

Antioxidant properties of the melatonin metabolite N1-acetyl-5-methoxykynuramine (AMK): scavenging of free radicals and prevention of protein destruction. Read More »

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