Melatonin in Mitochondria: Mitigating Clear and Present Dangers.


Reiter RJ, Ma Q, Sharma R




In: PHYSIOLOGY 35: 86–95, 2020.

Publication Link:

DOI Link:

In cancer cells, glucose is primarily metabolized to pyruvate and then to lactate in the cytosol.

By allowing the conversion of pyruvate to acetyl-CoA in mitochondria, melatonin reprograms glucose metabolism in cancer cells to a normal cell phenotype. Acetyl-CoA in the mitochondria also serves as a necessary co-factor for the rate-limiting enzyme in melatonin synthesis, thus ensuring melatonin production in mitochondria of normal cells.

Scroll to Top