Melatonin improves the oocyte and the embryo in IVF patients with sleep disturbances, but does not improve the sleeping problems.


Eryilmaz OG, Devran A, Sarikaya E, Aksakal FN, Mollamahmutoğlu L, Cicek N




J Assist Reprod Genet. 2011 Sep;28(9):815-20.

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We aimed to analyse the in vitro fertilization-embryo transfer (IVF-ET) outcomes of the patients with sleep disturbances who were administered melatonin.


A total of 60 patients with sleep disturbances were divided into two groups. The study group (group A, n=30) had underwent the IVF-ET with melatonin administration and the control group (group B, n=30) without melatonin. Sleeping status after melatonin administration and the IVF outcomes were compared between the two groups.


Sleeping status change was not significant (p>0.05). The mean number of the retrieved oocytes, the mean MII oocyte counts, the G1 embryo ratio were significantly higher in the melatonin administered group (group A) than that the non-administered group (group B); p=0.0001; p=0.0001; p<0.05 respectively.


IVF patients with sleep disorders may benefit from melatonin administration in improving the oocyte and the embryo quality, but the sleeping problem itself may not be fixed.

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