Background: Oocyte quality is one of the major deciding factors in female fertility competence.

Methods: PubMed database was searched for reviews by using the following keyword “oocyte quality” AND “Sirtuins”. The methodological quality of each literature review was assessed using the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) 2020 statement.

Main findings: Oxidative stress has been recognized as the mechanism attenuating oocyte quality. Increasing evidence from animal experiments and clinical studies has confirmed the protective roles of the sirtuin family in improving oocyte quality via an antioxidant effect.

Conclusion: The protective roles in the oocyte quality of the sirtuin family have been increasingly recognized.