Fertility
Medical Studies on Melatonin – Fertility
There have been studies on melatonin as an effective anti-cancer hormone for Fertility requires a healthy circadian rhythm, which is shaped by physiological melatonin levels. Any problem with the 24-hour cycle can have a negative impact on both female and male fertility.
Factors that prevent fertilisation
Factors include circadian rhythm disorders caused by jet lag and shift work, which adversely affects nocturnal melatonin production and ultimately prevents other hormones from being adequately produced. An impaired circadian rhythm also has a negative impact on the female menstruation cycle and can cause periods to become irregular or skipped, which can also have a negative impact on the reproductive system.
Melatonin and female fertility
Poor egg quality, often caused by oxidative stress, is considered to be one of the main causes of female infertility. With its anti-oxidative and anti-inflammatory properties, melatonin can prevent cells from being damaged by free radicals, which is especially important for ovulation. Especially in artificial fertilisation, eggs are exposed to even greater stresses. Researchers recommend that melatonin be administered before IVF in this case to improve egg quality.
Melatonin and male fertility
To improve male fertility, melatonin not only serves to increase the energy of the spermatozoa but also makes them faster and more agile. Melatonin also protects sperm from oxidative stress and improves its quality, which is essential to achieve successful fertilisation.
Medical Studies on Melatonin – Fertility
2012-01-02
The purpose of this study was to evaluate the association between the follicular fluid (FF) reactive oxygen species (ROS) levels, total antioxidant capacity (TAC) and ROS-TAC score and pregnancy after intracytoplasmic sperm injection (ICSI).
2011-11-01
Bisphenol A (BPA) is a monomer of polycarbonate plastic used to manufacture plastic baby bottles and lining of food cans. It has endocrine-disrupting potential and exerts both toxic and estrogenic effects on mammalian cells.
2011-09-20
This study investigated whether melatonin protects luteinized granulosa cells from reactive oxygen species (ROS) as an antioxidant to enhance progesterone production in the follicle during ovulation.
2011-09-05
We aimed to analyse the in vitro fertilization-embryo transfer (IVF-ET) outcomes of the patients with sleep disturbances who were administered melatonin.
2011-03-15
Although human seminal fluid contains melatonin and spermatozoa reportedly possess membrane melatonin receptors, there are no experimental studies that have ascertained the relationship between melatonin and male infertility.
2010-10-05
It is assumed somatic cells can die in the apoptotic, the autophagic, or the necrotic way; however, the mechanisms of sperm death are not clear.
2010-06-18
The aim of the study was to evaluate the efficacy of a treatment with myo-inositol plus folic acid plus melatonin compared with myo-inositol plus folic acid alone on oocyte quality in women underwent in vitro fertilization (IVF) cycles.
2010-04-16
Various systems of antioxidants exist endogenously in the body to help protect it against free radical damage by scavenging excessive ROS and RNS.
2009-07-20
To summarize the role of melatonin in the physiology and pathophysiology of the ovary.
2008-06-18
Mercury is one of the most investigated natural elements and potential contaminants in the environment. Antioxidants have long been known to reduce the free radical-induced oxidative damage.
2008-04-20
We investigated the relationship between oxidative stress and poor oocyte quality and whether the antioxidant melatonin improves oocyte quality.
2004-08-18
To summarize the role of melatonin and circadian rhythms in determining optimal female reproductive physiology, especially at the peripheral level.
Long-term melatonin administration does not alter pituitary-gonadal hormone secretion in normal men.
2000-01-12
The role of melatonin in the regulation of reproduction in humans is still controversial. In the present study the effects of melatonin were examined, 6 mg given orally every day at 1700 h for 1 month in a double-blind, placebo controlled fashion, on the nocturnal secretory profiles of luteinizing hormone (LH), follicle stimulating hormone (FSH), testosterone and inhibin beta in six healthy adult men.
1992-11-13
To examine the effect of night shift on the ovarian function, 122 teachers, 67 office workers, 377 nurses, 133 factory workers and 67 barmaids were surveyed.