Neurodegeneration
Medical Studies on Melatonin – Neurodegeneration
Melatonin also plays a key role in neuroprotection, because disruptions of the day/night cycle often have consequences for mental health. This has been proven on multiple occasions by studies. What’s more, the severity and course of diseases such as Alzheimer’s and Parkinson’s can be improved by melatonin.
Depression
Studies have observed that persons suffering from depression exhibit changes in their melatonin secretion and thus also their sleep/wake cycle. How we sleep is therefore also considered to be an important biomarker in the diagnosis, prevention and treatment of depression. By normalising these melatonin disorders, behaviour changes can be improved and depression mitigated.
Alzheimer’s and Parkinson’s disease
Low melatonin values, which are exhibited through daytime tiredness and nocturnal activity, are demonstrable in many Alzheimer’s and also Parkinson’s patients. Studies have been able to demonstrate that melatonin supplements administered for both of these diseases resulted in a significant improvement in symptoms, especially in the early stages of the disease.
Melatonin has a preventative effect
Melatonin has also been used to reduce oxidative stress in the brain and to reduce – or sometimes even prevent – the loss of nerve cells and damage to the brain. Melatonin is therefore primarily a preventative measure against Alzheimer’s and Parkinson’s disease. Studies are still under way to determine if it can be used in a curative capacity.
Medical Studies on Melatonin – Neurodegeneration
2025-01-17
A variety of organisms including mammals have evolved a 24h, self-sustained timekeeping machinery known as the circadian clock (biological clock),
2025-01-17
In type 2 diabetes mellitus (T2DM) and its related disorders like obesity, the abnormal protein processing, oxidative stress and proinflammatory
2025-01-17
The circadian system is an intricate molecular network of coordinating circadian clocks that organize the internal synchrony of the organism
2025-01-17
Disruptions of circadian rhythms and sleep cycles are common among neurodegenerative diseases and can occur at multiple levels. Accumulating evidence
2025-01-17
The brain lacks a classic lymphatic drainage system. How it is cleansed of damaged proteins, cellular debris, and molecular by-products
2025-01-09
Circadian rhythms are involved in the regulation of many aspects of the body, including cell function, physical activity and disease.
2025-01-09
Nutraceuticals and melatonergic pathway There is a growing dissatisfaction at the lack of progress in treating neurodegenerative conditions, such as
2022-07-18
Alterations in tryptophan and serotonin have been implicated in various mental disorders; but studies are limited on child neurodevelopmental disabilities
2022-07-12
An important pathophysiological component of Parkinson's Disease (PD) is circadian rhythm disorder, closely related to a decrease in circulated melatonin
2022-05-04
Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by a complex and multifaceted neurobehavioral syndrome. In the last decades,
2022-05-03
Intracellular accumulation of the microtubule-associated protein tau and its hyperphosphorylated forms is a key neuropathological feature of Alzheimer's disease (AD).
2022-03-19
Microglia, the sentinels of the central nervous system, are responsible for the surveillance and the innate defense against pathogen or
2020-07-19
This study aimed to determine the effect of exogenous melatonin on the number of sedative drugs and the duration of
2020-07-19
Secreted by the pineal gland to regulate the circadian rhythm, melatonin is a powerful antioxidant that has been used to
2020-05-24
Alzheimer's disease (AD) is a degenerative disease that is characterized by massive neuron devastations in the hippocampus and cortex. Mild
2020-05-15
This study evaluated the effects of melatonin supplementation on parameters of mental health, glycemic control, markers of cardiometabolic risk, and
2020-04-21
Growing evidence shows a link between mood and chronotype. The majority of studies measure chronotype as a preference for morning/evening
2020-04-16
This randomized, double-blinded, placebo-controlled trial tested the hypothesis that 20mg of melatonin before and during the first cycle of adjuvant
2020-03-19
The neuromodulator melatonin synchronizes circadian rhythms and related physiological functions via actions at two G protein-coupled receptors: MT1 and MT2.
2020-02-19
The bidirectional interaction between melatonin and the immune system has largely gone unexplored in a clinical context and especially in