gut microbiota

Melatonin alleviates airway inflammation and anxiety-depression in asthma via gut microbiota-SCFA axis-mediated inhibition of microglial activation

Clinical trials, Latest facts, Other diseases /

Background: Asthma frequently co-occurs with anxiety and depression, yet the mechanisms underlying this lung-brain comorbidity remain elusive. The gut-lung-brain axis has emerged as a potential key mediator. Methods: Using an ovalbumin (OVA)-induced murine asthma model, we administered melatonin or sodium butyrate via drinking water. We assessed airway inflammation, lung function, anxiety- and depression-like behaviors, gut microbiota composition,

Melatonin alleviates airway inflammation and anxiety-depression in asthma via gut microbiota-SCFA axis-mediated inhibition of microglial activation Read More »

Melatonin-Microbiome Two-Sided Interaction in Dysbiosis-Associated Conditions

Immune system /

Melatonin is a pineal indolamine, allegedly known as a circadian rhythm regulator, and an antioxidative and immunomodulatory molecule. In both experimental and clinical trials, melatonin has been shown to have positive effects in various pathologies, as a modulator of important biochemical pathways including inflammation, oxidative stress, cell injury, apoptosis, and energy metabolism. The gut represents

Melatonin-Microbiome Two-Sided Interaction in Dysbiosis-Associated Conditions Read More »

Melatonin as a Mediator of the Gut Microbiota-Host Interaction: Implications for Health and Disease

Immune system, Metabolism /

In recent years, the role played by melatonin on the gut microbiota has gained increasingly greater attention. Additionally, the gut microbiota has been proposed as an alternative source of melatonin, suggesting that this antioxidant indoleamine could act as a sort of messenger between the gut microbiota and the host. This review analyses the available scientific

Melatonin as a Mediator of the Gut Microbiota-Host Interaction: Implications for Health and Disease Read More »

Scroll to Top